Protective Effect of CoQ10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiovascular Surgery (PANDA V)
Protective Effect of Coenzyme Q10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiac and Aortic Surgery (PANDA V): a Randomized Controlled Trial
Nanjing Medical University
500 participants
Feb 1, 2021
INTERVENTIONAL
Conditions
Summary
Cardiovascular diseases are the leading causes of death and prescription drug use. Research on certain dietary supplements looks promising as a way to help reduce risk factors. Previous studies showed that CoQ10 levels were decreased in cardiovascular patients and worsening of mitochondrial dysfunction was observed. The overall objective of this study is to determine if supplementing with CoQ10 can reduce inflammatory risk factors in adults with cardiac surgery, independent of other dietary or physical activity changes.
Eligibility
Inclusion Criteria3
- Adult men and women
- Who receive cardiovascular surgery
- Agree to participate in the surgery and sign the informed consent form
Exclusion Criteria3
- Pregnant or planning on getting pregnant during the study
- Contain a minimum of 2 traits of metabolic syndrome
- Refused to participate in the surgery and refused informed consent
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Interventions
Coenzyme Q10 is a cardiovascular health supplement. It is a component of the electron transport chain and participates in aerobic cellular respiration, which generates energy in the form of ATP. The ingredients in Coenzyme Q10 help regulate the body's production of free radicals, strengthen the arteries and heart, and reverse oxidation.
Patients only received standard medical therapy without CoQ10.
Locations(4)
View Full Details on ClinicalTrials.gov
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NCT04444349