Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine

This study tests whether colchicine — an inexpensive anti-inflammatory medication often used for gout — can protect the heart in people with chronic kidney disease. People with kidney disease often develop a type of heart damage, and this study investigates whether reducing inflammation can help. **You may be eligible if...** - You are 21 to 80 years old - You have reduced kidney function (eGFR between 15 and 75) - Your urine test shows elevated protein levels (albumin-to-creatinine ratio above 30) - You are on maximum tolerated doses of standard kidney-protective medications (ACE inhibitor or ARB) if applicable **You may NOT be eligible if...** - You are already on dialysis or have had a kidney transplant - You have active liver disease - You have a history of colchicine intolerance - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.