Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia

This study is testing a new radiation device called DaRT (Diffusing Alpha-emitters Radiation Therapy) — small seeds inserted into a tumor that release targeted alpha radiation — for patients with skin, mouth, or soft tissue tumors who cannot receive or have failed standard treatments. **You may be eligible if...** - You are 18 or older with confirmed malignant skin, oral, or superficial soft tissue cancer - Your tumor is 7 cm or smaller - The tumor can be fully reached and covered by the DaRT seeds - You have either already tried standard treatment (surgery, radiation, or chemotherapy) and it failed, OR you are not a candidate for standard treatment, OR you have declined standard treatment - Your general health is reasonable (ECOG performance status 0–2) **You may NOT be eligible if...** - Your tumor is larger than 7 cm - Your tumor cannot be safely accessed for seed placement - You have rapidly spreading disease or poor overall health Talk to your doctor to see if this trial is right for you.