RecruitingPhase 1NCT04589624

An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy

Pilot Study of Metabolic Guidance for Therapy in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck


Sponsor

M.D. Anderson Cancer Center

Enrollment

42 participants

Start Date

Aug 12, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This trial investigates whether hyperpolarized magnetic resonance imaging (hpMRI) can predict treatment response in patients with thyroid cancer and other malignancies of the head and neck undergoing radiation therapy and/or receiving systemic therapy before surgery. An hpMRI is like a standard MRI but involves the use of an imaging contrast agent called hyperpolarized 13-C-pyruvate. Diagnostic procedures, such as hpMRI, may predict a patient's response to treatment and may help plan the best treatment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses a special type of MRI scan — called hyperpolarized MRI — to track how well radiation or drug treatments are working in people with thyroid cancer or other head and neck cancers. This scan can give real-time information about how cancer cells are using energy, helping doctors make better treatment decisions. **You may be eligible if...** - You have been diagnosed with thyroid cancer or another cancer of the head or neck - You are currently planned for radiation therapy and/or systemic drug treatment **You may NOT be eligible if...** - You have severe claustrophobia (fear of enclosed spaces) - You have metal implants or devices (like a pacemaker) that are not MRI-compatible - You have a history of irregular heart rhythms - You are allergic to MRI contrast dye (Gadavist) - Your kidney function is significantly impaired - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHyperpolarized Carbon C 13 Pyruvate

Given IV

PROCEDUREMagnetic Resonance Imaging

Undergo MRI

PROCEDUREMagnetic Resonance Imaging

Undergo hpMRI


Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT04589624


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