RecruitingNot ApplicableNCT05229341

Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules

Evaluation of DNA Methylation Signatures in Diagnosis and Management of Thyroid Nodules

Sponsor

City of Hope Medical Center

Enrollment

1,450 participants

Start Date

Oct 22, 2021

Study Type

INTERVENTIONAL

Conditions

Thyroid Gland Carcinoma

Summary

This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether DNA methylation patterns detected in thyroid nodule biopsy samples can help doctors more accurately diagnose whether a nodule is cancerous or benign, reducing unnecessary surgeries. **You may be eligible if...** - You are 18 or older - You are already scheduled to have a needle biopsy of a thyroid nodule as part of your normal care - You are of any gender, race, or ethnicity - You are willing to consent to having your tissue and clinical data used for research **You may NOT be eligible if...** - You are under 18, because thyroid nodule biology in children is different from adults Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREDiagnostic Procedure

Analysis via DDMS-2

OTHERElectronic Health Record Review

Review of medical records

PROCEDURENeedle Biopsy

Undergo needle biopsy

Locations(1)

City of Hope Medical Center

Duarte, California, United States

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NCT05229341

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