RecruitingNCT04596592

Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth

Sponsor

University of Colorado, Denver

Enrollment

90 participants

Start Date

Feb 15, 2021

Study Type

OBSERVATIONAL

Conditions

Gender Dysphoria Insulin Sensitivity Transgenderism

Summary

To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.

Eligibility

Min Age: 13 YearsMax Age: 16 Years

Inclusion Criteria5

Identify as a transgender female
Age 13-16 years at the time of enrollment
If on a gonadotropin releasing hormone analogue, \> 6 months exposure
Plan to start estradiol clinically in \< 4 months
Males and females ages 13-16 years

Exclusion Criteria8

Cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures
Antipsychotic medication use
Type 1 or 2 diabetes (by medical history)
Polycystic ovarian syndrome (PCOS for cisgender females)
Hypertension (resting BP ≥ 140/90 mm/Hg)
Weight\> 400 lbs
On oral progesterone medications (including oral progesterone or progestin, combined oral contraceptives or etonogestrel implant)
Pregnancy (for cisgender females)

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