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RecruitingNCT04690972

"Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Enrollment

800 participants

Start Date

Jan 14, 2021

Study Type

OBSERVATIONAL

Conditions

Liver CancerNon-Alcoholic Fatty Liver DiseaseNon Alcoholic SteatohepatitisChronic Liver Disease and CirrhosisViral Hepatitis BViral Hepatitis CViral Hepatitis D

Summary

Development of preclinical translational models for chronic liver tumors and diseases study, such as spheroids cultured in autologous medium and murine xenograft models to test the efficacy of new therapeutic strategies.

Eligibility

Min Age: 18 Years

Inclusion Criteria7

  • Patients
  • diagnosed with chronic liver disease (viral or not)
  • diagnosed with at least one liver nodule for which a biopsy is planned as part of the care
  • for hepatobiliary surgery planned as part of care
  • for locoregional treatment for HCC is indicated
  • Patients able to receive and understand information relating to the study and give their written informed consent
  • Patients affiliated to the French social security system

Exclusion Criteria6

  • Minor patients
  • Patients under legal protection,
  • Patients subject to legal protection or unable to express their consent,
  • Patients in a situation of social fragility,
  • Pregnant or breastfeeding woman,
  • No signing of informed consent.

Interventions

PROCEDUREBlood sample during surgery

During the hepato-bilio-pancreatic surgery, blood is drawn.

PROCEDURETaking an additional biopsy

As part of the treatment, an additional biopsy is executed and blood is drawn.

DIAGNOSTIC_TESTBlood sample during diagnostic test

Blood sample as part of the care

Locations(1)

PU-PH, Directeur de l'UMR_S1110 Unité Inserm d'affiliation : UMR_S1110

Strasbourg, France

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NCT04690972

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