Monotherapy of an NMDA Enhancer for Schizophrenia

This study tests whether an NMDA enhancer drug — a medication that boosts a chemical signaling system in the brain thought to be underactive in schizophrenia — can help manage symptoms on its own without traditional antipsychotic medications. **You may be eligible if...** - You have a confirmed diagnosis of schizophrenia (DSM-5 criteria) - You are unwilling or unable to tolerate antipsychotic medications due to side effects or poor response - Your symptom score (PANSS total) is 60 or higher, indicating significant symptoms - You have been off antipsychotic drugs for at least 1 week - You are able to provide informed consent **You may NOT be eligible if...** - You have a current substance use problem or history of dependence in the past 3 months - You have epilepsy, a history of serious head injury, or stroke - You have a serious physical illness that would complicate participation - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.