Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
Wake Forest University Health Sciences
220 participants
Aug 18, 2021
INTERVENTIONAL
Conditions
Summary
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.
Eligibility
Inclusion Criteria7
- verified HIV status
- Current marijuana use (MJ+ groups only)
- No current marijuana use (MJ- groups only)
- current engagement in HIV care (HIV+ participants only)
- receipt of cART as first-line of treatment (HIV+ participants only)
- stable cART regimen (HIV+ participants only)
- undetectable HIV RNA viral load for \>1 year (HIV+ participants only)
Exclusion Criteria8
- Lifetime abuse for any illicit drug other than marijuana
- \<9th grade education; illiteracy or lack of fluency in English
- history of moderate or severe head trauma
- unstable or serious neurological disorders
- severe mental illness
- systemic autoimmune diseases
- immunotherapy
- MRI contraindications
Interventions
The investigators will use multimodal, multi-parametric sequences to investigate neuroinflammatory and neurodegenerative processes in vivo. Participants will be assessed three times over 2 years.
Blood samples will be collected for immune and cytokine profiling. Participants will be assessed three times over 2 years.
Participants will have neuropsychological testing three times over 2 years.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT04810858