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RecruitingNot ApplicableNCT04810858

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Sponsor

Wake Forest University Health Sciences

Enrollment

220 participants

Start Date

Aug 18, 2021

Study Type

INTERVENTIONAL

Conditions

InflammationHIVCognitionCannabisNeuroimaging

Summary

This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.

Eligibility

Min Age: 25 YearsMax Age: 59 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how regular marijuana use affects brain inflammation and nerve damage in people living with HIV, using brain scans and biological samples. It aims to understand whether marijuana use worsens, improves, or has no effect on HIV-related brain injury. **You may be eligible if...** - You have a confirmed HIV diagnosis - You are in active HIV care and on stable treatment (cART) with an undetectable viral load for more than 1 year (for HIV-positive participants) - You use marijuana regularly (for marijuana-using groups) OR do not use marijuana (for comparison groups) **You may NOT be eligible if...** - You use other illicit substances (beyond marijuana) - You have a history of serious neurological conditions unrelated to HIV - You are unable to safely undergo brain imaging Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMultimodal, multi-parametric MRI

The investigators will use multimodal, multi-parametric sequences to investigate neuroinflammatory and neurodegenerative processes in vivo. Participants will be assessed three times over 2 years.

OTHERImmune and cytokine profiling

Blood samples will be collected for immune and cytokine profiling. Participants will be assessed three times over 2 years.

BEHAVIORALNeuropsychological testing

Participants will have neuropsychological testing three times over 2 years.

Locations(1)

Biotech Place

Winston-Salem, North Carolina, United States

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NCT04810858

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