RecruitingNot ApplicableNCT04853212

The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis

The Role of Dysbiosis of Intestinal Microbiota in the Development of Spondyloarthritis

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

100 participants

Start Date

Jun 14, 2021

Study Type

INTERVENTIONAL

Conditions

Spondyloarthritis Ruminococcus Gnavus

Summary

The primary objective of this case-control study aims to explore the role of bacterium Ruminococcus gnavus (R. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (SPA) in comparison with health control subjets (patients without chronic disease but have indication to digestive endoscopy).

Eligibility

Min Age: 18 Years

Inclusion Criteria10

Patients with SPA:
Patients ⩾ 18 years;
Diagnosed as spondyloarthritis (SpA) according ASAS classification;
Affiliated to a social security scheme;
Have signed the written informed consent form.
Control subjects:
Subjects ⩾ 18 years;
Subjects free of SPA and planned for a digestive endoscopy for another indication such as to explore the risk of colorectal cancer in family member;
Affiliated to a social security scheme;
Have signed the written informed consent form.

Exclusion Criteria7

Subjects unable to understand the proposed study and/or sign a informed consent form;
Pregnant women or breast feeding women;
Subjects under guardianship or curatorship;
Have taken antibiotic 1 month prior to inclusion;
Presenting acute or chronic severe pathology may likely to interfere with the interpret of outcome;
Refusal of subjects to participate to the study;
Foreign patients under french AME scheme.