RecruitingNCT04869813

Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

Sarcopenia Characterization Using Magnetic Resonance Fingerprinting and Phosphorous Magnetic Resonance Spectroscopic Imaging Evaluation (SUSIE)


Sponsor

The Cleveland Clinic

Enrollment

70 participants

Start Date

Apr 9, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.


Eligibility

Min Age: 40 Years

Inclusion Criteria7

  • Heart failure patients
  • Age ≥40 yrs
  • Stable chronic heart failure
  • Systolic dysfunction determined by cardiac MRI with left ventricle ejection fraction 40% or less
  • Healthy Volunteers
  • Age ≥40 yrs
  • No diagnosed heart failure or sarcopenia

Exclusion Criteria14

  • Heart failure patients
  • Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease
  • Healthy volunteers (controls)
  • Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease
  • Contraindications to MRI Contraindications to MRI
  • Heart pacemaker/defibrillator
  • Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires
  • Cochlear implant or other ear implants
  • Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity)
  • Programmable shunt
  • Aneurysm clips and coils
  • Stents
  • Filters (for example, blood clot filters)
  • Metal fragment in body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings)

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Locations(1)

Cleveland Clinic

Cleveland, Ohio, United States

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NCT04869813


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