Repurposing Low-Dose Clonidine for PTSD in Veterans

This trial tests whether low-dose clonidine — a medication originally used for high blood pressure — can reduce PTSD symptoms, especially nightmares and intrusive memories, in military veterans. Clonidine reduces norepinephrine activity in the brain, which may calm the overactive stress response seen in PTSD. **You may be eligible if...** - You are a US military veteran aged 18 or older with a confirmed PTSD diagnosis - You score at least 40 on the PCL-5 PTSD symptom checklist - You have significant intrusion symptoms (flashbacks, nightmares) and hyperarousal symptoms - You speak and understand English - You are willing to attend clinic visits as scheduled **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are at moderate or high risk of suicide - You have severe unstable mental illness (active schizophrenia, uncontrolled bipolar, significant traumatic brain injury) - You are currently in exposure-based therapy or recently started another behavioral health therapy - Your blood pressure is urgently high (above 160/100) Talk to your doctor to see if this trial is right for you.