RecruitingNCT04916210

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

Sponsor

Massachusetts General Hospital

Enrollment

8,000 participants

Start Date

Mar 5, 2021

Study Type

OBSERVATIONAL

Conditions

Ischemic Stroke Dementia, Vascular Mild Cognitive Impairment Subarachnoid Hemorrhage Intracerebral Hemorrhage Vascular Cognitive Impairment

Summary

The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). The investigators hypothesize that: 1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery. 2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke. 3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study — called DISCOVERY — is following people after they have had a stroke or brain bleed to understand what causes some people to develop cognitive problems (memory and thinking difficulties) afterward, while others recover well. The study tracks brain changes over time using imaging, blood tests, and cognitive assessments. You may be eligible if: - You are 18 years or older - You have been admitted to a hospital with a diagnosis of acute ischemic stroke, intracerebral hemorrhage (brain bleed), or aneurysmal subarachnoid hemorrhage - You can complete the baseline visit (in person or by phone) within 6 weeks of your stroke - You are fluent in English or Spanish before your stroke - You or your proxy can provide informed consent You may NOT be eligible if: - You have a documented history of dementia before the stroke - You are already enrolled in a conflicting study - Your condition or directives make it impossible to complete the study - You have contraindications to MRI (pacemaker, cochlear implants, metal implants in the brain) — for Tier 2 participants - You are under 50 years old, pregnant, or have certain genetic cancer risk conditions — for Tier 3 participants Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(31)

Barrow Neurological Institute

Phoenix, Arizona, United States

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States

Cedars Sinai Medical Center

Los Angeles, California, United States

University of California Los Angeles

Los Angeles, California, United States

University of California San Diego

San Diego, California, United States

University of Colorado

Denver, Colorado, United States

Mayo Clinic

Jacksonville, Florida, United States

University of Miami Health System

Miami, Florida, United States

The University of Chicago Medical Center

Chicago, Illinois, United States

Indiana University

Indianapolis, Indiana, United States

University of Iowa

Iowa City, Iowa, United States

University of Maryland Medical Center

Baltimore, Maryland, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Boston Medical Center

Boston, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

University of Minnesota Health

Minneapolis, Minnesota, United States

Mayo Clinic

Rochester, Minnesota, United States

University of Mississippi Medical Center

Jackson, Mississippi, United States

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Montefiore Medical Center

The Bronx, New York, United States

Duke University Medical Center

Durham, North Carolina, United States

Wake Forest Baptist Health

Winston-Salem, North Carolina, United States

University of Cincinnati

Cincinnati, Ohio, United States

The Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Methodist University Hospital

Memphis, Tennessee, United States

Houston Methodist Research Institute

Houston, Texas, United States

UTHealth

Houston, Texas, United States

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

University of Utah

Salt Lake City, Utah, United States

University of Virginia

Charlottesville, Virginia, United States

University of Washington, Harborview Medical Center

Seattle, Washington, United States

View Full Details on ClinicalTrials.gov

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NCT04916210

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