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RecruitingNCT05025254

Cognitive Testing Online in Parkinson's Disease

Deep Cognitive Endophenotyping of Parkinson's Disease: A Platform Development and Pilot Study

Sponsor

McGill University

Enrollment

1,000 participants

Start Date

Aug 1, 2021

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease

Summary

This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research. Thus a large part of this pilot study will be to demonstrate feasibility and reliability, and use this experience to develop a feasible protocol for ongoing research. The specific short-term objectives are: 1. To establish the feasibility of performing large-scale deep cognitive phenotyping using online cognitive testing. 2. To demonstrate that online neurocognitive testing is valid and reliable in a smaller sample of locally recruited participants tested both in-lab and online.

Eligibility

Min Age: 45 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether online cognitive tests can accurately detect thinking and memory changes in people with Parkinson's disease — from home, without needing to visit a clinic. The goal is to make cognitive testing faster and more accessible. **You may be eligible if...** - You have been diagnosed with Parkinson's disease by a neurologist, OR - You are a healthy person with no neurological diagnosis and willing to serve as a comparison participant **You may NOT be eligible if...** - You have a psychotic disorder - You have active, uncontrolled depression - You have advanced dementia (needing help with basic daily activities like dressing or bathing) - You have had a major stroke, serious head injury, or epilepsy requiring seizure medication Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNeurocognitive testing

We are assessing several cognitive domains and have made minor adaptations (reducing the total number of trials or lengthening response windows) to several standard neuropsychology tests including measures of executive function, working memory, visuospatial function, declarative memory, reward processing, response inhibition. Overall, the tests we use follow a standard set-up: participants are shown stimuli on the screen and are asked to provide a response using either a keyboard or a mouse, based on a specific set of instructions. We always provide a detailed set of on-screen instructions and a practice phase. In some cases, information about performance is provided in the form of points, in other cases, none is provided.

Locations(1)

McGill University Health Centre

Montreal, Quebec, Canada

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NCT05025254

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