RecruitingNCT05033288

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone

Sponsor

Mayo Clinic

Enrollment

72 participants

Start Date

Jan 20, 2022

Study Type

OBSERVATIONAL

Conditions

Chondrosarcoma Bone Sarcoma Chordoma Ewing Sarcoma of Bone Pelvic Rhabdomyosarcoma

Summary

This study compares carbon ion therapy, surgery, and proton therapy to determine if one has better disease control and fewer side effects. There are three types of radiation treatment used for pelvic bone sarcomas: surgery with or without photon/proton therapy, proton therapy alone, and carbon ion therapy alone. The purpose of this study is to compare quality of life among patients treated for pelvic bone sarcomas across the world, and to determine if carbon ion therapy improves quality of life compared to surgery and disease control compared with proton therapy.

Eligibility

Min Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This trial directly compares three treatments for bone-involved pelvic sarcomas (rare, aggressive bone tumors in the pelvis): carbon ion therapy (a new, precise radiation), proton therapy (another form of precision radiation), and surgery. It aims to help determine which approach leads to the best outcomes. **You may be eligible if...** - You are 15 or older - You have a newly diagnosed pelvic sarcoma involving bone (e.g., chordoma, chondrosarcoma, Ewing sarcoma, osteosarcoma, or certain soft tissue sarcomas) - Your cancer has not spread to other parts of the body - You are in reasonably good health (ECOG 0–2) - You are willing to use contraception if applicable **You may NOT be eligible if...** - You are under 15 years old - Your cancer has spread (metastatic disease) - You previously received radiation to the same area - Your disease is recurrent (came back) - You are receiving palliative (comfort-focused) treatment only Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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