RecruitingNot ApplicableNCT05065151

Understanding Motivation in Parkinson's Patients Through Neurophysiology


Sponsor

University of California, San Francisco

Enrollment

70 participants

Start Date

Oct 30, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how Parkinson's disease or dystonia (a movement disorder causing involuntary muscle contractions) affects motivation — the drive to initiate and sustain actions. Researchers record brain signals directly from implanted deep brain stimulation (DBS) devices to understand what happens in the brain during motivated behavior. **You may be eligible if...** - You have been diagnosed with Parkinson's disease or dystonia - You already have a Medtronic Percept or RC+S deep brain stimulation device implanted in the GPI or STN brain region - You are more than 1 month post-surgery and 18 or older **You may NOT be eligible if...** - You have severe cognitive impairment (MoCA score below 20) - You are pregnant - You are under 18 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERStimulation on

Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.

OTHERStimulation off

Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.

BEHAVIORALDecision Making Task

Patients will be playing a decision making task through a computer-based application.


Locations(1)

University of California San Francisco

San Francisco, California, United States

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NCT05065151


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