Amygdala Memory Enhancement
Mechanisms of Amygdala-Mediated Memory Enhancement in Humans
Washington University School of Medicine
90 participants
Nov 1, 2021
INTERVENTIONAL
Conditions
Summary
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.
Eligibility
Inclusion Criteria5
- Must be able to understand and speak English.
- Able to provide informed consent.
- Diagnosed with epilepsy.
- Scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization.
- Must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices.
Exclusion Criteria3
- Unable to understand and speak English.
- Unable to provide informed consent.
- Not diagnosed with epilepsy.
Interventions
Electrodes localized to the BLA will be stimulated with either active-BLAES (0.5-3.5 mA, theta-modulated gamma burst) electrical stimulation for a 1-sec duration immediately following item image presentation or sham-BLAES (zero-amplitude). At later stages of the project, stimulation parameters and timing will be varied and triggered not at random, but by real-time closed-loop analysis of memory biomarkers in the medial temporal lobe.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05065450