RecruitingNot ApplicableNCT05065450

Amygdala Memory Enhancement

Mechanisms of Amygdala-Mediated Memory Enhancement in Humans

Sponsor

Washington University School of Medicine

Enrollment

90 participants

Start Date

Nov 1, 2021

Study Type

INTERVENTIONAL

Conditions

Cognitive Impairment Traumatic Brain Injury Brain Diseases Epilepsy Memory Disorders Post Traumatic Stress Disorder

Summary

The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether electrical stimulation of the amygdala (a brain region involved in emotional memory) can enhance memory formation in people with epilepsy who are already undergoing brain monitoring with implanted electrodes. This research could lead to therapies for memory disorders. **You may be eligible if...** - You have been diagnosed with epilepsy - You are already scheduled for long-term intra-cranial video monitoring to locate your seizures - Your implanted electrodes include coverage of the amygdala, hippocampus, and nearby brain regions - You can understand and speak English **You may NOT be eligible if...** - You do not have epilepsy - You are unable to provide informed consent - Your electrodes do not cover the required brain areas Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEIntracranial Stimulation

Electrodes localized to the BLA will be stimulated with either active-BLAES (0.5-3.5 mA, theta-modulated gamma burst) electrical stimulation for a 1-sec duration immediately following item image presentation or sham-BLAES (zero-amplitude). At later stages of the project, stimulation parameters and timing will be varied and triggered not at random, but by real-time closed-loop analysis of memory biomarkers in the medial temporal lobe.

Locations(1)

Washington University School of Medicine

St Louis, Missouri, United States

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NCT05065450

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