RecruitingNCT05077618

Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study

Oral Bacterial and Viral Mapping by Dental Plaque in Elderly Patients With and Without Alzheimer's Disease(ORal MICrobiology in Alzheimer's Patients)

Sponsor

Centre Hospitalier Universitaire de Nice

Enrollment

94 participants

Start Date

Jan 30, 2023

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Periodontitis

Summary

The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority. This project is based on the assumption that the oral cavity represents a privileged observation space to address these issues. The mouth is a site of easy access for painless sampling; there is therefore a major interest in identifying early oral infectious markers of the development or evolution of senile dementia. In addition to the interest of an early oral diagnosis, the mapping of the oral microbial flora in the demented elderly would allow a better understanding, prevention or even control of the evolution of neurodegenerative diseases. The final objective of our approach is to characterize the oral pathogens, or more probably the group of oral pathogens, which are significantly associated with Alzheimer's disease.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the mouth bacteria (oral microbiome) of elderly people with and without Alzheimer's disease to understand whether gum disease-related bacteria might be linked to Alzheimer's development. **You may be eligible if...** - You are 70 years old or older - For the Alzheimer's group: you have a diagnosis of possible or probable Alzheimer's disease - For the control group: you are cognitively healthy - You are affiliated with a social security scheme **You may NOT be eligible if...** - You have another neurodegenerative or cognitive disorder - You have had cancer (including mouth or throat cancer) - You have autoimmune diseases (HIV, hepatitis), inflammatory diseases (rheumatoid arthritis), or serious cardiovascular, kidney, liver, or lung conditions - You had oral surgery in the last 2 months - You took antibiotics or anti-inflammatory drugs in the last 4 weeks - You are on oral anticoagulants, bisphosphonates, anticonvulsants, or oral retinoids Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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