RecruitingNCT05077618

Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study

Oral Bacterial and Viral Mapping by Dental Plaque in Elderly Patients With and Without Alzheimer's Disease(ORal MICrobiology in Alzheimer's Patients)

Sponsor

Centre Hospitalier Universitaire de Nice

Enrollment

94 participants

Start Date

Jan 30, 2023

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Periodontitis

Summary

The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority. This project is based on the assumption that the oral cavity represents a privileged observation space to address these issues. The mouth is a site of easy access for painless sampling; there is therefore a major interest in identifying early oral infectious markers of the development or evolution of senile dementia. In addition to the interest of an early oral diagnosis, the mapping of the oral microbial flora in the demented elderly would allow a better understanding, prevention or even control of the evolution of neurodegenerative diseases. The final objective of our approach is to characterize the oral pathogens, or more probably the group of oral pathogens, which are significantly associated with Alzheimer's disease.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria4

ge greater than or equal to 70 years old
Patient (or trusted person) having read and understood the study information note and signed the informed consent form
Membership in a social security scheme
for cases : Diagnosis of possible or probable Alzheimer's disease according to the DSM-V

Exclusion Criteria12

Presence of a neurodegenerative pathology (excluding Alzheimer's disease for cases)
Presence of a neurocognitive disorder (excluding Alzheimer's disease for the cases)
Patient with or having had any kind of cancer, including oral or aerodigestive tract
Patients with or having had autoimmune diseases (HIV, hepatitis)
Patients with inflammatory diseases (such as rheumatoid arthritis (RA) or Gougerot-Sjogren's syndrome (GSJ))
Patients with severe haemopathy
Patients with severe acute or chronic cardiovascular, renal, hepatic, gastrointestinal, allergic, endocrine, pulmonary, neuropsychiatric pathologies, judged by the investigator to be incompatible with the study, as all these pathologies may interfere with the results of the oral flora sampling
Patients who have undergone oral surgery in the two months prior to sampling
Patients treated with oral retinoids, bisphosphonates, oral anticoagulants or anticonvulsants
Patients who have had anti-cancer or immunosuppressive chemotherapy within the last 6 months
Patient who has had antibiotic or anti-inflammatory treatment in the last 4 weeks
A history of treatments (drugs and probiotics) taken in the month prior to sampling will be taken, as well as a record of toxic habits (tobacco, alcohol, other)