Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

This study investigates whether treating depression in people living with HIV improves brain function and immune health. It uses brain MRI scans and immune markers to understand the link between mood and the immune system in HIV. **You may be eligible if...** - You are 18 or older - You are HIV-positive and on antiretroviral (HIV) medications - You have been diagnosed with major depression - Your HIV viral load is suppressed (below 200 copies/mL) - You are able to have an MRI scan (no claustrophobia, no metal implants, BMI under 40) **You may NOT be eligible if...** - You are not on HIV medication - Your HIV is not virologically suppressed - You cannot have an MRI (claustrophobia, pacemaker, metal implants) Talk to your doctor to see if this trial is right for you.