Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure

This study is testing whether a medication that blocks inflammation (anakinra, which blocks a protein called interleukin-1) given shortly after a heart attack can prevent the development of heart failure in the weeks and months that follow. **You may be eligible if:** - You are over 21 years old - You have had a specific type of heart attack (ST-elevation myocardial infarction, or STEMI) with chest pain starting within the past 12 hours - You have had or are planned to have a procedure to open the blocked artery (like a stent) - You are able to give consent **You may NOT be eligible if:** - You are pregnant - You have had a previous heart attack or have existing heart failure - You are allergic to anakinra or products derived from E. coli - Your chest pain has been ongoing continuously for more than 12 hours - The artery-opening procedure was not successful - You need emergency open-heart surgery - You have an active infection - You are unable to do a treadmill exercise test at your follow-up visit Talk to your doctor to see if this trial is right for you.