RecruitingNot ApplicableNCT05290363

The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis

Sponsor

Institut Pasteur

Enrollment

90 participants

Start Date

Oct 6, 2022

Study Type

INTERVENTIONAL

Conditions

Spondyloarthritis

Summary

This is a research study involving humans, of the interventional type with minimal risks and constraints (RIPH2). It is a multicentric, non randomized prospective study aiming to better understand the mechanisms of the response to anti-IL-23 biologics in Spondyloarthritis patients attending the rheumatology department of Cochin, Saint-Antoine, Henri-Mondor hospitals (APHP) and Maison-Blanche Hospital (Reims).

Eligibility

Min Age: 18 Years

Inclusion Criteria20

Age : Adults (>18 years)
Satisfying ASAS diagnostic criteria for SpA
Patient has active disease, defined by the presence of active synovitis, tendinitis, or dactylitis or significant inflammatory pain of the spine, judged by the examining clinician to be due to SpA.
Informed consent signed
Beneficiary of health insurance, except for the AME
Only for patients of Group 1 • Patient is naïve to biological therapies
Only for patients of Group 2
Patient is affected by peripheral SpA (ASAS criteria) or psoriatic arthritis, with inflammation of peripheral joints
Patient requires aspiration, as part of standard care
Patient is minor
Patient is pregnant or breastfeeding
Patient is immunocompromised
Patient has received biological therapy with 2 or more biologics
Patient is receiving corticosteroid treatment > 10 mg per day
Patient is under legal protection, curators, guardianship
Patient refuses consent
Previous history of alcoholism, drug addiction, psychological problems, severe concomitant conditions that could invalidate the patient's consent or limit the patient's compliance to the treatment protocol.
Beneficiary of the AME
Only for group 1
Patient has received biological therapy

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Interventions

OTHERBlood sampling

A 51 mL blood sample will be collected during the study

OTHERsynovial aspiration

If synovial aspiration is required in standard care for patients with peripheral spondylarthritis. Medical waste product will be collected for the study