Early Aortic vaLve surgEry Versus wAtchful waitiNg Strategy in Severe Asymptomatic aOrtic reguRgitation
Early Aortic Valve Surgery Versus Watchful Waiting Strategy in Severe Asymptomatic Aortic Regurgitation
Na Homolce Hospital
217 participants
Sep 1, 2022
INTERVENTIONAL
Conditions
Summary
The optimal timing of surgical intervention in asymptomatic patients with severe aortic regurgitation remains controversial. As per cardiac magnetic resonance assessment, early surgical treatment will be compared with conventional guideline-based strategy in asymptomatic patients with severe aortic regurgitation.
Eligibility
Inclusion Criteria4
- Chronic asymptomatic aortic regurgitation grade 3 (moderate to severe) and grade 4 (severe)
- No indication for the surgical treatment at the time of enrolment
- LV ejection fraction \>50%
- Absence of more than mild-to-moderate concomitant valve disease or complex congenital heart disease
Exclusion Criteria5
- Age \<18 years
- Clearance Creatinine \<30 mL/min
- Contraindication for magnetic resonance (implanted active device, ferromagnetic implant incompatible with magnetic resonance scanner, cerebral aneurysm clip, metallic fragment in the eye or near sensitive tissue)
- Pregnancy
- Permanent atrial fibrillation.
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Interventions
Optimal surgical treatment (aortic valve-sparing surgery, aortic valve replacement, Ross procedure).
Locations(8)
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NCT05438862