RecruitingEarly Phase 1NCT05493722

Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy


Sponsor

University of Minnesota

Enrollment

20 participants

Start Date

Sep 15, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • medically refractory epilepsy
  • already have a deep brain stimulator in place

Exclusion Criteria1

  • severe dementia at investigator discretion

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Interventions

OTHERPS and OS stimulation order 1

PS, OS, OS

OTHERPS and OS stimulation order 2

OS, PS, OS

OTHERPS and OS stimulation order 3

OS, OS, PS


Locations(1)

University of Minnesota

Minneapolis, Minnesota, United States

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NCT05493722


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