RecruitingEarly Phase 1NCT05493722

Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy

Sponsor

University of Minnesota

Enrollment

20 participants

Start Date

Sep 15, 2023

Study Type

INTERVENTIONAL

Conditions

Refractory Epilepsy Deep Brain Stimulation

Summary

Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

Some people with epilepsy that does not respond to medication are treated with deep brain stimulation (DBS) — a surgically implanted device that delivers electrical pulses to specific areas of the brain. This study tests whether adjusting the stimulation settings in a personalized way leads to better seizure control than standard settings. You may be eligible if: • You are 18 years old or older • You have medically refractory epilepsy (seizures that do not respond to medication) • You already have a deep brain stimulator implanted You may NOT be eligible if: • You have severe dementia (as determined by the investigator) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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