The Effect of SAAE on Ventricular Remodeling in PA Patients
The Effect of Selective Adrenal Artery Embolization and Spironolactone on Ventricular Remodeling in Nondominant Lateral Secretory Primary Aldosteronism： A Randomized Controlled Clinical Study
Second Affiliated Hospital of Nanchang University
112 participants
Sep 1, 2022
INTERVENTIONAL
Conditions
Summary
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
Eligibility
Inclusion Criteria5
- (1) Age 18-60 years old, regardless of gender;
- (2) Blood pressure conditions meet one of the following: 1) Office blood pressure ≥ 140/90mmHg; 2) Ambulatory blood pressure monitoring whole day blood pressure > 130/80 mmHg or daytime blood pressure > 135/85 mmHg;
- (3) After strict drug elution, it met the diagnostic criteria of primary aldosteronism, and bilateral primary aldosteronism was confirmed by adrenal venous sampling;
- (4) No surgical intent or contraindication to surgery and willing to undergo pharmacological treatment or percutaneous superselective adrenal artery embolization;
- (5) The patient or his/her legal representative shall sign the written informed consent approved by the ethics committee before the screening.
Exclusion Criteria7
- (1) Primary hypertension or secondary hypertension with other causes;
- (2) A woman who is pregnant or lactating, or has a birth plan for the next year;
- (3) There are serious organic diseases, especially liver and kidney dysfunction(eGFR<45 mL/min/1.73 m2);
- (4) Severe allergy to contrast medium;
- (5) Other serious organic diseases, life expectancy < 12 months;
- (6) Adrenal CT showed adenoma.;
- (7) Patients are enrolled or want to participate in other clinical studies. During the enrollment study, the results of this study will be affected.
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Interventions
Superselective adrenal arterial embolization is an operation to inject embolic agent into adrenal artery through catheter to embolize part of adrenal gland, so as to reduce the secretion of adrenal hormone and reduce blood pressure.
Aldosterone receptor antagonists are recommended by guidelines for the treatment of bilateral primary aldosteronism.
Locations(1)
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NCT05501080