RecruitingPhase 3NCT05519085

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1

Sponsor

Celgene

Enrollment

810 participants

Start Date

Sep 20, 2022

Study Type

INTERVENTIONAL

Conditions

Relapsed or Refractory Multiple Myeloma

Summary

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing a new 3-drug combination (mezigdomide + bortezomib + dexamethasone) against a standard treatment (pomalidomide + bortezomib + dexamethasone) in patients with multiple myeloma (a blood cancer) that has come back after 1–3 prior treatments. **You may be eligible if...** - You have been diagnosed with multiple myeloma - Your cancer is measurable by specific lab tests (M-protein or free light chains) - You have received 1–3 prior lines of treatment and had at least a minimal response to one of them **You may NOT be eligible if...** - Your cancer progressed while on, or within 60 days of stopping, certain proteasome inhibitor drugs (with some exceptions) - You did not respond at all to a previous bortezomib-containing treatment, or you stopped bortezomib due to bad side effects - You have previously received mezigdomide or pomalidomide - You have other significant health conditions per the study protocol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGmezigdomide

Specified dose on specified days

DRUGPomalidomide

Specified dose on specified days

DRUGBortezomib

Specified dose on specified days

DRUGDexamethasone

Specified dose on specified days

Locations(266)

Local Institution - 0366

Los Alamitos, California, United States

Local Institution - 0272

San Diego, California, United States

Local Institution - 0273

West Hollywood, California, United States

Local Institution - 0381

Aurora, Colorado, United States

Local Institution - 0380

Farmington, Connecticut, United States

Local Institution - 0208

New Haven, Connecticut, United States

Local Institution - 0303

Coral Springs, Florida, United States

Local Institution - 0403

Fort Myers, Florida, United States

Local Institution - 0401

St. Petersburg, Florida, United States

Local Institution - 0402

West Palm Beach, Florida, United States

Local Institution - 0211

Athens, Georgia, United States

Local Institution - 0048

Marietta, Georgia, United States

Local Institution - 0330

Garden City, Kansas, United States

Local Institution - 0080

Westwood, Kansas, United States

Local Institution - 0358

Baton Rouge, Louisiana, United States

Local Institution - 0255

New Orleans, Louisiana, United States

Local Institution - 0385

Shreveport, Louisiana, United States

Local Institution - 0357

Baltimore, Maryland, United States

Local Institution - 0246

Boston, Massachusetts, United States

Local Institution - 0271

Ann Arbor, Michigan, United States

Local Institution - 0364

Detroit, Michigan, United States

Local Institution - 0410

Minneapolis, Minnesota, United States

Local Institution - 0088

Hattiesburg, Mississippi, United States

Local Institution - 0242

Jackson, Mississippi, United States

Local Institution - 0288

East Brunswick, New Jersey, United States

Local Institution - 0363

Ridgewood, New Jersey, United States

Local Institution - 0302

Albuquerque, New Mexico, United States

Local Institution - 0245

Buffalo, New York, United States

Local Institution - 0257

Lake Success, New York, United States

Local Institution - 0373

New Hyde Park, New York, United States

Local Institution - 0371

New York, New York, United States

Local Institution - 0108

Rochester, New York, United States

Local Institution - 0374

Shirley, New York, United States

Local Institution - 0372

The Bronx, New York, United States

Local Institution - 0274

Williamsville, New York, United States

Local Institution - 0260

Durham, North Carolina, United States

Local Institution - 0400

Cincinnati, Ohio, United States

Local Institution - 0377

Cleveland, Ohio, United States

Local Institution - 0076

Cleveland, Ohio, United States

Local Institution - 0376

Mayfield Heights, Ohio, United States

Local Institution - 0359

Allentown, Pennsylvania, United States

Local Institution - 0264

York, Pennsylvania, United States

Local Institution - 0223

Germantown, Tennessee, United States

Local Institution - 0378

Abilene, Texas, United States

Local Institution - 0275

Houston, Texas, United States

Local Institution - 0267

San Antonio, Texas, United States

Local Institution - 0409

San Antonio, Texas, United States

Local Institution - 0207

Salt Lake City, Utah, United States

Local Institution - 0297

Fredericksburg, Virginia, United States

Local Institution - 0408

Norfolk, Virginia, United States

Local Institution - 0399

Roanoke, Virginia, United States

Local Institution - 0268

Seattle, Washington, United States

Local Institution - 0293

Seattle, Washington, United States

Local Institution - 0097

Spokane, Washington, United States

Local Institution - 0411

Vancouver, Washington, United States

Local Institution - 0220

Madison, Wisconsin, United States

Local Institution - 0318

Chivilcoy, Buenos Aires, Argentina

Local Institution - 0213

Buenos Aires, Buenos Aires F.D., Argentina

Local Institution - 0249

Córdoba, Córdoba Province, Argentina

Local Institution - 0239

Viedma, R, Argentina

Local Institution - 0200

Rosario, Santa Fe Province, Argentina

Local Institution - 0248

S3000epv, Santa Fe Province, Argentina

Local Institution - 0214

Buenos Aires, Argentina

Local Institution - 0055

Liverpool, New South Wales, Australia

Local Institution - 0004

Waratah, New South Wales, Australia

Local Institution - 0017

Wollongong, New South Wales, Australia

Local Institution - 0327

Birtinya, Queensland, Australia

Local Institution - 0221

Box Hill, Victoria, Australia

Local Institution - 0003

Melbourne, Victoria, Australia

Local Institution - 0002

Melbourne, Victoria, Australia

Local Institution - 0040

Nedlands, Western Australia, Australia

Klinik Ottakring

Vienna, State of Vienna, Austria

Universitätsklinikum Krems

Krems, Austria

LKH Hochsteiermark - Standort Leoben

Leoben, Austria

Universitätsklinikum St. Pölten

Sankt Pölten, Austria

Hanusch-Krankenhaus

Vienna, Austria

Ziekenhuis Oost-Limburg, Campus St.-Jan

Genk, Limburg, Belgium

UZ Gent

Ghent, Oost-Vlaanderen, Belgium

AZ Nikolaas

Sint-Niklaas, Oost-Vlaanderen, Belgium

ZNA Cadix

Antwerp, Belgium

Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador

Salvador, Estado de Bahia, Brazil

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa

Porto Alegre, Rio Grande do Sul, Brazil

Instituto Joinvilense de Hematologia e Oncologia

Joinville, Santa Catarina, Brazil

Hospital Amaral Carvalho

Jaú, São Paulo, Brazil

Americas Centro de Oncologia Integrado

Rio de Janeiro, Brazil

Clínica Médica São Germano S/S Ltda

São Paulo, Brazil

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

São Paulo, Brazil

Local Institution - 0225

Greenfield Park, Quebec, Canada

Local Institution - 0174

Montreal, Quebec, Canada

Local Institution - 0222

Québec, Quebec, Canada

Local Institution - 0329

Santiago, Santiago Metropolitan, Chile

Local Institution - 0387

Santiago, Santiago Metropolitan, Chile

Local Institution - 0332

Viña del Mar, Valparaiso, Chile

Local Institution - 0062

Beijing, Beijing Municipality, China

Local Institution - 0165

Beijing, Beijing Municipality, China

Local Institution - 0141

Beijing, Beijing Municipality, China

Local Institution - 0144

Chongqing, Chongqing Municipality, China

Local Institution - 0237

Xiamen, Fujian, China

Local Institution - 0117

Guangzhou, Guangdong, China

Local Institution - 0177

Guangzhou, Guangdong, China

Local Institution - 0168

Guangzhou, Guangdong, China

Local Institution - 0238

Shenzhen, Guangdong, China

Local Institution - 0412

Liuzhou, Guangxi, China

Local Institution - 0240

Nanning, Guangxi, China

Local Institution - 0254

Shijiazhuang, Hebei, China

Local Institution - 0395

Luoyang, Henan, China

Local Institution - 0113

Zhengzhou, Henan, China

Local Institution - 0142

Wuhan, Hubei, China

Local Institution - 0155

Changsha, Hunan, China

Local Institution - 0147

Changsha, Hunan, China

Local Institution - 0111

Nanjing, Jiangsu, China

Local Institution - 0139

Wuxi, Jiangsu, China

Local Institution - 0287

Shenyang, Liaoning, China

Local Institution - 0148

Xi'an, Shaanxi, China

Local Institution - 0110

Xi'an, Shaanxi, China

Local Institution - 0169

Qingdao, Shandong, China

Local Institution - 0114

Shanghai, Shanghai Municipality, China

Local Institution - 0350

Shanghai, Shanghai Municipality, China

Local Institution - 0164

Taiyuan, Shanxi, China

Local Institution - 0356

Deyang, Sichuan, China

Local Institution - 0119

Tianjin, Tianjin Municipality, China

Local Institution - 0353

Ürümqi, Xinjiang, China

Local Institution - 0202

Kunming, Yunnan, China

Local Institution - 0151

Hangzhou, Zhejiang, China

Local Institution - 0348

Linhai, Zhejiang, China

Local Institution - 0112

Ningbo, Zhejiang, China

Local Institution - 0149

Wenzhou, Zhejiang, China

Local Institution - 0150

Beijing, China

Local Institution - 0176

Taiyuan, China

Local Institution - 0037

Brno, Brno-město, Czechia

Local Institution - 0383

Prague, Praha 10, Czechia

Local Institution - 0039

Prague, Czechia

Local Institution - 0256

Kuopio, Northern Savonia, Finland

Local Institution - 0072

Helsinki, Finland

Institut de cancérologie Strasbourg Europe (ICANS)

Strasbourg, Alsace, France

CHU Bordeaux Haut-Leveque

Pessac, Aquitaine, France

Centre Leon Berard

Lyon Cedex08, Auvergne-Rhône-Alpes, France

Hopital Claude Huriez - CHU de Lille

Lille, Nord, France

Centre Hospitalier Universitaire Estaing

Clermont-Ferrand, France

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren

Limoges, France

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu

Nantes, France

Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau

Nîmes, France

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau

Tours, France

Hôpital Saint Antoine

Paris, Île-de-France Region, France

TUM Klinikum

München, Bavaria, Germany

Klinikum Traunstein

Traunstein, Bavaria, Germany

Medizinisches Versorgungszentrum

Weiden, Bavaria, Germany

Universitätsklinikum Marburg

Marburg, Hesse, Germany

Praxis Onkologie am Raschplatz

Hanover, Lower Saxony, Germany

Universitätsklinikum Bonn

Bonn, North Rhine-Westphalia, Germany

Marien Hospital Düsseldorf

Düsseldorf, North Rhine-Westphalia, Germany

Universitaetsklinikum Schleswig-Holstein Campus Kiel

Kiel, Schleswig-Holstein, Germany

Local Institution - 0396

Erfurt, Thuringia, Germany

Universitätsklinikum Aachen

Aachen, Germany

Sozialstiftung Bamberg

Bamberg, Germany

Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf

Dresden, Germany

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany

Asklepios Altona

Hamburg, Germany

Universitaetsklinikum Tuebingen

Tübingen, Germany

Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher

Würzburg, Germany

Evangelismos General Hospital of Athens

Athens, Attikí, Greece

Alexandra General Hospital of Athens

Athens, Attikí, Greece

G. Papanikolaou General Hospital

Thessaloniki, Thessaloníki, Greece

HCG Aastha Cancer Centre

Ahmedabad, Gujarat, India

Marengo Asia Hospitals Gurugram

Gurugram, Haryana, India

KLES Dr. Prabhakar Kore Hospital & M.R.C

Belagavi, Karnataka, India

Mumbai Oncocare Centre - Nanachowk

Mumbai, Maharashtra, India

Meenakshi Mission Hospital and Research Centre

Madurai, Tamil Nadu, India

Tata Memorial Centre - Homi Bhabha Cancer Hospital

Varanasi, Uttar Pradesh, India

Christian Medical College & Hospital

Ludhiana, India

Jawaharlal Institute Of Postgraduate Medical Education And Research

Puducherry, India

Local Institution - 0121

Galway, Connacht, Ireland

Local Institution - 0122

Cork, Ireland

Local Institution - 0120

Dublin, Ireland

Local Institution - 0251

Limerick, Ireland

Meir Medical Center

Kfar Saba, Central District, Israel

Sheba Medical Center

Ramat Gan, Central District, Israel

Hadassah Medical Center - Do Not Use - Duplicate Facility

Jerusalem, Jerusalem, Israel

Rambam Health Care Campus

Haifa, Northern District, Israel

Sourasky Medical Center

Tel Aviv, Tall Abīb, Israel

Rabin Medical Center

Peatch Tikva, Israel

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"

Meldola, Emilia-Romagna, Italy

Azienda Ospedaliera Sant'Andrea

Rome, Roma, Italy

Policlinico "G. Rodolico"

Catania, Sicily, Italy

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola

Bologna, Italy

Fondazione IRCCS Policlinico San Matteo

Pavia, Italy

National Cancer Center Hospital East

Kashiwa, Chiba, Japan

Japan Community Healthcare Organization Kyushu Hospital

Kitakyushu-shi, Fukuoka, Japan

National Hospital Organization Hokkaido Cancer Center

Sapporo, Hokkaido, Japan

Mito Medical Center

Higashiibaraki, Ibaraki, Japan

Iwate Medical University Hospital

Shiwa-gun Yahaba-cho, Iwate, Japan

Shonan Kamakura General Hospital

Kamakura, Kanagawa, Japan

Saitama Medical University Hospital

Iruma, Saitama, Japan

Dokkyo Medical University Saitama Medical Center

Koshigaya, Saitama, Japan

Shizuoka Cancer Center

Nagaizumi-cho,Sunto-gun, Shizuoka, Japan

Nihon University Itabashi Hospital

Itabashiku, Tokyo, Japan

Chiba University Hospital

Chiba, Japan

National Hospital Organization Kyushu Medical Center

Fukuoka, Japan

Japanese Red Cross Fukuoka Hospital

Fukuoka, Japan

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Hiroshima, Japan

Kumamoto University

Kumamoto, Japan

The Japanese Red Cross Nagasaki Genbaku Hospital

Nagasaki, Japan

The Jikei University Hospital

Tokyo, Japan

Japanese Red Cross Medical Center

Tokyo, Japan

Local Institution - 0335

Tauranga, Bay of Plenty, New Zealand

Local Institution - 0340

Dunedin, Otago, New Zealand

Local Institution - 0369

Auckland, New Zealand

Local Institution - 0334

Auckland, New Zealand

Local Institution - 0346

Skórzewo, Greater Poland Voivodeship, Poland

Local Institution - 0224

Torun, Kuyavian-Pomeranian Voivodeship, Poland

Local Institution - 0325

Krakow, Lesser Poland Voivodeship, Poland

Local Institution - 0250

Warsaw, Masovian Voivodeship, Poland

Local Institution - 0292

Słupsk, Pomeranian Voivodeship, Poland

Local Institution - 0185

Katowice, Poland

Hospital de Braga

Braga, Portugal

Champalimaud Foundation

Lisbon, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil, EPE

Porto, Portugal

Local Institution - 0355

San Juan, Puerto Rico

Fundeni Clinical Institute

Bucharest, Romania

Institutul Oncologic Cluj

Cluj-Napoca, Romania

Institutul Regional de Oncologie Iasi

Iași, Romania

Netcare Pretoria East Hospital

Centurion, GP, South Africa

Groote Schuur Hospital

Cape Town, Western Cape, South Africa

Haemalife

Kuilsriver, Western Cape, South Africa

Constantiaberg Haematology

Plumstead, Western Cape, South Africa

Local Institution - 0106

Busan, Busan, South Korea

Pusan National University Hospital

Busan, Busan, South Korea

Local Institution - 0102

Seongnam, Gyeonggido, South Korea

Seoul National University Bundang Hospital

Seongnam, Gyeonggido, South Korea

Chonnam National University Hwasun Hospital

Hwasun, Jeonranamdo, South Korea

Local Institution - 0103

Hwasun, Jeonranamdo, South Korea

Local Institution - 0101