RecruitingPhase 1Phase 2NCT07116616

A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma

A Phase 1/2, Open-label, Multicenter Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma


Sponsor

ModernaTX, Inc.

Enrollment

166 participants

Start Date

Sep 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the safety and tolerability of mRNA-2808 in participants with relapsed or refractory multiple myeloma (RRMM).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial tests an experimental mRNA-based therapy called mRNA-2808 in people with multiple myeloma (a blood cancer) that has come back or stopped responding to prior treatments. The drug is designed to help the immune system recognize and attack myeloma cells. **You may be eligible if...** - You have relapsed or refractory multiple myeloma - You have previously been treated with a proteasome inhibitor, an immunomodulatory drug (IMiD), and an anti-CD38 antibody - You still have measurable disease (detectable markers in blood, urine, or bone marrow) **You may NOT be eligible if...** - You have not had prior exposure to the required standard treatments - You have conditions that make your myeloma or organ function too unstable - Additional exclusion criteria apply (ask your study team for full details) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGmRNA-2808

intravenous


Locations(10)

University of Alabama at Birmingham Hospital

Birmingham, Alabama, United States

UCSF

San Francisco, California, United States

Emory University Hospital

Atlanta, Georgia, United States

Mass General Brigham

Boston, Massachusetts, United States

Tisch Cancer Institute at Mount Sinai

New York, New York, United States

Memorial Sloan-Kettering Cancer Center

New York, New York, United States

Atrium Health Levine Cancer Institute

Charlotte, North Carolina, United States

Penn Medicine

Philadelphia, Pennsylvania, United States

Sarah Cannon Research Institute

Nashville, Tennessee, United States

The Medical College of Wisconsin

Milwaukee, Wisconsin, United States

View Full Details on ClinicalTrials.gov

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NCT07116616


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