RecruitingPhase 1Phase 2NCT07116616
A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma
A Phase 1/2, Open-label, Multicenter Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma
Sponsor
ModernaTX, Inc.
Enrollment
166 participants
Start Date
Sep 30, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to evaluate the safety and tolerability of mRNA-2808 in participants with relapsed or refractory multiple myeloma (RRMM).
Eligibility
Min Age: 18 Years
Plain Language Summary
Simplified for easier understanding
This trial tests an experimental mRNA-based therapy called mRNA-2808 in people with multiple myeloma (a blood cancer) that has come back or stopped responding to prior treatments. The drug is designed to help the immune system recognize and attack myeloma cells.
**You may be eligible if...**
- You have relapsed or refractory multiple myeloma
- You have previously been treated with a proteasome inhibitor, an immunomodulatory drug (IMiD), and an anti-CD38 antibody
- You still have measurable disease (detectable markers in blood, urine, or bone marrow)
**You may NOT be eligible if...**
- You have not had prior exposure to the required standard treatments
- You have conditions that make your myeloma or organ function too unstable
- Additional exclusion criteria apply (ask your study team for full details)
Talk to your doctor to see if this trial is right for you.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
DRUGmRNA-2808
intravenous
Locations(10)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07116616
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