RecruitingPhase 1NCT06604715

A Study of JNJ-87562761 in Participants With Relapsed or Refractory Multiple Myeloma

A Phase 1, First-in-Human, Open-Label, Dose Escalation Study of JNJ-87562761 in Relapsed/Refractory Multiple Myeloma


Sponsor

Janssen Research & Development, LLC

Enrollment

80 participants

Start Date

Dec 19, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine the recommended phase 2 dose(s) (RP2D\[s\]) of JNJ-87562761 in Part 1 (dose escalation), and to determine the safety and tolerability at RP2D in Part 2 (dose expansion) in participants with multiple myeloma (MM) whose disease has come back after treatment (relapsed) or hasn't responded to treatment (refractory).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is an early-phase study testing a new drug called JNJ-87562761 in people with multiple myeloma — a cancer of plasma cells in the bone marrow — whose disease has come back or stopped responding to prior treatments. **You may be eligible if...** - You have been diagnosed with multiple myeloma that has relapsed (come back) or is refractory (no longer responding to treatment) - Your disease is still measurable through blood, urine, or protein tests - You have already been treated with at least three types of prior therapies, including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 therapy - You have good performance status (able to carry out most daily activities) - Your kidneys are functioning adequately **You may NOT be eligible if...** - You have not received the required prior therapies - You have significant kidney impairment - You do not meet performance status requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGJNJ-87562761

JNJ-87562761 will be administered.


Locations(15)

Princess Margaret Hospital

Toronto, Ontario, Canada

Jewish General Hospital

Montreal, Quebec, Canada

Seoul National University Hospital

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

The Catholic University of Korea Seoul St Marys Hospital

Seoul, South Korea

Hosp. Univ. Germans Trias I Pujol

Badalona, Spain

Hosp Clinic de Barcelona

Barcelona, Spain

Hosp Univ Fund Jimenez Diaz

Madrid, Spain

Clinica Univ. de Navarra

Pamplona, Spain

Hosp Clinico Univ de Salamanca

Salamanca, Spain

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

China Medical University Hospital

Taichung, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06604715


Related Trials