A Study Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)
An Open-Label, Multicenter, Phase Ib Trial Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Patients With Relapsed or Refractory Multiple Myeloma
Genentech, Inc.
120 participants
Aug 10, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of the study is to evaluate safety and tolerability of the combination of cevostamab plus elranatamab and also determine the recommended Phase II regimen (RP2R) for the study treatment. The study consists of a safety lead-in stage, and an expansion stage.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Cevostamab solution for infusion will be administered as IV as specified in each treatment arm.
Elranatamab solution for injection will be administered SC as specified in each treatment arm.
Tocilizumab will be used as rescue medication for participants who experience a cytokine release syndrome (CRS) event.
Locations(14)
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NCT05927571