RecruitingNCT05574153

Metabolic Risk Factors and Myocardial Oxygenation Reserve

Metabolic Risk Factors and Myocardial Oxygenation Reserve (META-MORE)

Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Enrollment

75 participants

Start Date

Jun 30, 2021

Study Type

OBSERVATIONAL

Conditions

Metabolic Syndrome

Summary

The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria8

Patient Participants:
Age 18-80
Informed Consent
Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels)
Healthy Volunteers:
Age 18-80
No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system
No Smoking

Exclusion Criteria3

General MRI contraindications*
Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam

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Interventions

DIAGNOSTIC_TESTCardiac MRI

Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.