The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study

This study is testing whether a dose of caffeine given before surgery can reduce the risk of postoperative delirium — a state of confusion and disorientation that commonly occurs in older patients after surgery. Delirium after surgery can lead to longer hospital stays and worse long-term outcomes. **You may be eligible if...** - You are 70 years or older - You are having non-cardiac, non-brain surgery under general anesthesia - You are expected to stay in the hospital for at least 48 hours after surgery - You are willing and able to follow study procedures **You may NOT be eligible if...** - Your surgery is an emergency - You have a history of seizures - You have a caffeine intolerance or allergy - You weigh more than 130 kg - You have severe cognitive impairment that would prevent consent - You are enrolled in another conflicting study Talk to your doctor to see if this trial is right for you.