RecruitingNot ApplicableNCT05590130

Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and Oxygenation


Sponsor

Laval University

Enrollment

40 participants

Start Date

Nov 16, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators recently evaluated 4 different oximeters among the most commonly used with arterial catheter in place and compared SpO2 with SaO2 obtained on arterial gas. Correlations between SaO2 and SpO2 were poor for all oximeters, as previously known, and SpO2-SaO2 bias were different between oximeters. Some oximeters (Masimo, Nellcor) had lower biases but they detected less well hypoxemia. Some oximeters underestimated SaO2 (Nonin) but detected very well hypoxemia, and some overestimated SaO2 (Philips). The investigators concluded that oximeters provide different informations to clinicians, and oxygenation targets should take into account for these differences. The assumption is that the SpO2 target AND oximeter used will both have an impact on oxygen flows and that these effects will add up. With a high SpO2 target, oxygen flows will be significantly greater and with the Nonin oximeter, the required flows will be greater than with the Philips oximeter. NB: the results obtained were in a population with light skin pigmentation (96% of the patients were Fitzpatrick 1-2, reflecting the local hospitalized population).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study compares two different oxygen level targets and two different pulse oximeters (devices that measure oxygen in the blood) in patients recovering from heart surgery in the intensive care unit. The goal is to find out which approach leads to better oxygen management and whether certain oximeters are more accurate after cardiac surgery. You may be eligible if: - You are 18 years of age or older - You have been admitted to a cardiac surgery ICU after an operation - You have an arterial catheter in place - Your blood oxygen levels fall within a specific range while receiving supplemental oxygen You may NOT be eligible if: - Your pulse oximeter cannot get a reliable reading - You have false nails or nail polish (which interfere with the oximeter) - You have elevated methemoglobin levels on your last blood gas test - You are in isolation due to a resistant infection or COVID-19 - You are expected to be placed on non-invasive ventilation or high-flow oxygen within an hour Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEManual Oxygen titration with Philips oximeter (SpO2 target 90%)

Oxygen titration with FreeO2 device (fixed flow mode) to reach the SpO2 target (set at 90%) with Philips oximeter

DEVICEManual oxygen titration with Nonin oximeter (SpO2 target 90%)

Oxygen titration with FreeO2 device (fixed flow mode) to reach the SpO2 target (set at 90%) with Nonin oximeter

DEVICEManual Oxygen titration with Philips oximeter (SpO2 target 94%)

Oxygen titration with FreeO2 device (fixed flow mode) to reach the SpO2 target (set at 94%) with Philips oximeter

DEVICEManual oxygen titration with Nonin oximeter (SpO2 target 94%)

Oxygen titration with FreeO2 device (fixed flow mode) to reach the SpO2 target (set at 94%) with Philips oximeter


Locations(1)

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Québec, Quebec, Canada

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NCT05590130


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