Venetoclax and Bomedemstat in Patients With Relapsed/Refractory Acute Myeloid Leukemia

This study tests a combination of two drugs — venetoclax and bomedemstat — for people with acute myeloid leukemia (AML), a type of blood cancer, that has come back or stopped responding to previous treatment. Both drugs work in different ways to kill cancer cells, and researchers are investigating whether using them together is safe and effective. **You may be eligible if...** - You have been diagnosed with AML (a type of blood cancer) that has returned or stopped responding to at least one standard treatment - You are 18 years or older - Your heart, liver, and kidney function meet the study's requirements **You may NOT be eligible if...** - You have a certain type of AML called acute promyelocytic leukemia (APL/M3) - You have active brain involvement from your cancer - You are currently taking certain medications that interact with the study drugs - You have certain serious health conditions that would make participation unsafe Talk to your doctor to see if this trial is right for you.