RecruitingNot ApplicableNCT05629819

Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients

Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients:A Multicenter, Randomized Controlled Study


Sponsor

Bing Sun

Enrollment

104 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether applying non-invasive electrical stimulation to the phrenic nerve (the nerve that controls the diaphragm) early during mechanical ventilation helps patients breathe independently sooner and reduces the time they spend on a ventilator. It targets patients in the ICU who are expected to need a breathing machine for at least 3 days. **You may be eligible if...** - You are between 18 and 80 years old - You have been on a mechanical ventilator for 48 hours or less - You are expected to need the ventilator for at least 72 hours total - The chest and shoulder areas needed for the device are accessible - You or your family member has consented to participate **You may NOT be eligible if...** - You have a collapsed lung, active tuberculosis, or pleural adhesions - You have a pacemaker or defibrillator - You have a neuromuscular disease like myasthenia gravis - You are on a heart-lung bypass (ECMO) machine - You have an unstable heartbeat or blood pressure instability - You are pregnant - You are in the terminal phase of illness or receiving only palliative care Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICENon-invasive phrenic nerve stimulation

Some studies have shown that PNS can relieve diaphragmatic atrophy and reverse diaphragmatic dysfunction.


Locations(1)

Bing Sun

Beijing, Beijing Municipality, China

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NCT05629819


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