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RecruitingNot ApplicableNCT05629819

Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients

Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients：A Multicenter, Randomized Controlled Study

Sponsor

Bing Sun

Enrollment

104 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Mechanical VentilationWeaning

Summary

the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria5

  • Age ≥18years and ≤80years;
  • MV time ≤48h;
  • MV duration is expected to be ≥72h;
  • The sternocleidomastoid region and pectoralis major region were completely exposed.
  • Patients or family members are willing to sign informed consent and participate in the study.

Exclusion Criteria7

  • There are contraindications to PNS in vitro (Pneumothorax, active tuberculosis, pleural adhesions, installation of pacemakers and defibrillators, etc.);
  • Neuromuscular disease (myasthenia gravis, etc.) or known anatomical abnormalities of the diaphragm;
  • ECMO status;
  • Hemodynamic instability;
  • Uncorrected arrhythmias;
  • Be pregnant;
  • Clinical end-stage and palliative care patients.

Interventions

DEVICENon-invasive phrenic nerve stimulation

Some studies have shown that PNS can relieve diaphragmatic atrophy and reverse diaphragmatic dysfunction.

Locations(1)

Bing Sun

Beijing, Beijing Municipality, China

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NCT05629819

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