RecruitingNCT06532994

Predictive Algorithms for Critical Rehabilitation Outcomes

Development and Validation of a Prediction Algorithms to Estimate the Clinical Effect of Early Rehabilitation on ICU Survivors Received Mechanical Ventilation in the ICU

Sponsor

Wuhan University

Enrollment

250 participants

Start Date

Aug 1, 2024

Study Type

OBSERVATIONAL

Conditions

Mechanical Ventilation Rehabilitation Intensive Care Algorithms

Summary

An increasing amount of evidence from evidence-based medicine indicates that early rehabilitation intervention for patients receiving mechanical ventilation is safe and feasible, and can promote functional recovery and reduce hospital stay. However, the conscious state, respiratory function, and daily living activities of these patients after being discharged from the ICU vary greatly, and some patients do not show obvious benefits. How to identify which patients may have benefit from early rehabilitation is a key issue that needs to be addressed in critical care rehabilitation. This study aims to investigate the clinical data related to the disease of the ICU survivors who received mechanical ventilation as the research object, by collecting their clinical data when receiving early rehabilitation intervention, and constructing a clinical prediction model for the efficacy of early rehabilitation intervention in the ICU through the selection of optimal regression equation or machine learning algorithm. The application of this model can effectively determine whether ICU inpatients need early rehabilitation intervention, thereby reducing complication rates and improving their quality of life.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria5

Age older than 18 years;
Received mechanical ventilation, including endotracheal intubation and tracheostomy, during ICU admission;
Met the rehabilitation intervention indications outlined in the "Chinese Expert Consensus on Neurocritical Rehabilitation" during ICU admission and underwent corresponding early rehabilitation interventions, including but not limited to arousal therapy for consciousness disorders, early active/passive mobilization, comprehensive pulmonary rehabilitation, etc.;
No mortality events occurred during ICU admission;
Informed consent form signed by family members or the patient.

Exclusion Criteria6

Pediatric patients under 18 years of age;
Hospitalized patients in the ICU who did not receive mechanical ventilation;
Patients in the ICU who did not undergo early rehabilitation interventions;
mortality events occurred during ICU admission;
Patients transferred out of the ICU due to treatment abandonment by family members;
Family refusal to sign the informed consent form or patient refusal to sign the informed consent form when conscious and competent.

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Interventions

OTHEREarly rehabilitation intervention

Based on the indications for early rehabilitation intervention outlined in the "Chinese Expert Consensus on Neurological Critical Care Rehabilitation," early rehabilitation interventions are categorized into three stages according to the patient's consciousness level (GCS score), degree of cooperation (S5Q score), and sedation status (RASS score)