Weaning Clinical Trials

44 recruitingLast updated: June 18, 2026

There are 44 actively recruiting weaning clinical trials across 19 countries. Studies span Not Applicable, Phase 4. Top locations include Istanbul, Istanbul, Turkey (Türkiye), Lyon, France, Istanbul, Turkey (Türkiye). Updated daily from ClinicalTrials.gov.


Weaning Trials at a Glance

44 actively recruiting trials for weaning are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in Istanbul, Lyon, and Istanbul. Lead sponsors running weaning studies include Assistance Publique - Hôpitaux de Paris, Cairo University, and Centre Hospitalier Régional d'Orléans.

Browse weaning trials by phase

Treatments under study

About Weaning Clinical Trials

Looking for clinical trials for Weaning? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Weaning trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Weaning clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 44 trials

Recruiting
Not Applicable

High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients

High Flow Oxygen TherapyTracheostomized PatientsMechanical Ventilation Weaning
King Faisal Specialist Hospital & Research Center88 enrolled1 locationNCT07559591
Recruiting
Not Applicable

Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials

Weaning Invasive Mechanical VentilationWeaning-induced Pulmonary EdemaWeaning Failure of Mechanical Ventilation+2 more
Centre Hospitalier Régional d'Orléans24 enrolled1 locationNCT06923267
Recruiting

D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients

Chronic Obstructive Pulmonary Disease (COPD)Mechanical Ventilator Weaning
Sohag University100 enrolled1 locationNCT07590362
Recruiting

Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial

Mechanical VentilationWeaningStrains+3 more
Centre Hospitalier Universitaire, Amiens60 enrolled1 locationNCT06009731
Recruiting

Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients

Respiratory InsufficiencyCritical IllnessWeaning Failure of Mechanical Ventilation+1 more
Istanbul University - Cerrahpasa105 enrolled1 locationNCT07571317
Recruiting

A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score

extubation failureRespiratory FailureWeaning Invasive Mechanical Ventilation+5 more
Medipol University470 enrolled7 locationsNCT07098611
Recruiting

Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients

Weaning Invasive Mechanical Ventilation
Fu Jen Catholic University Hospital100 enrolled1 locationNCT07455214
Recruiting

Use of a Physiotherapy Assessment to Predict Extubation Failure in Mechanically Ventilated Patients: the EPIC Assessment

Mechanical VentilationMechanical Ventilator Weaning
Assistance Publique - Hôpitaux de Paris330 enrolled1 locationNCT06450678
Recruiting
Not Applicable

A Randomized Clinical Trial for Predictors of Successful Extubation of Pediatric Patients With or Without High Velocity Nasal Insufflation

High Velocity Nasal InsufflationSimple OxygenWeaning Criteria
Cairo University100 enrolled1 locationNCT07383051
Recruiting
Not Applicable

Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU

Weaning Failure
KU Leuven90 enrolled1 locationNCT04658498
Recruiting
Not Applicable

Speckle Tracking Echocardiography for the Prediction of Weaning Failure

Weaning Failure of Mechanical Ventilation
Assistance Publique Hopitaux De Marseille110 enrolled1 locationNCT03657524
Recruiting

External Validation of VVI

weaning mechanical ventilation
University of Thessaly100 enrolled3 locationsNCT07372664
Recruiting

Weaning Ventilator Using Heart, Lung And Diaphragm Ultrasound

UltrasoundVentilator Weaning
Hanoi Medical University190 enrolled1 locationNCT06321848
Recruiting
Not Applicable

Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients

Ventilator Weaning
Hospices Civils de Lyon50 enrolled3 locationsNCT06499389
Recruiting
Not Applicable

Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients.

Weaning FailureVentilator-induced Diaphragm DysfunctionVIDD
Tesai Care SL20 enrolled3 locationsNCT07363902
Recruiting
Phase 4

Shorter Weaning From Invasive Ventilation With Levosimendan

Mechanical VentilationWeaning Failure
Radboud University Medical Center250 enrolled8 locationsNCT07105202
Recruiting
Not Applicable

Endotracheal Suctionning During Positive Pressure Extubation in ICU

Weaning Invasive Mechanical VentilationExtubationOxygen Saturation Measurement+2 more
Centre Hospitalier Régional d'Orléans120 enrolled1 locationNCT07130123
Recruiting

Evaluation of Mechanical Power and Ventilator Parameters to Predict Weaning Success in the Intensive Care Unit

weaning mechanical ventilationMechanical PowerNegative Inspiratory Force+1 more
Anıl Berkay Balıtatlı60 enrolled1 locationNCT07268989
Recruiting

Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit

Oxygen consumptionMechanical VentilationCritical Illness+4 more
Leiden University Medical Center60 enrolled1 locationNCT07109570
Recruiting
Not Applicable

Optimal Timing for Spontaneous Breathing Trials

WeaningRespiration, Artificial
Rush University Medical Center348 enrolled1 locationNCT06561295