RecruitingNCT05649800

Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project

Evaluating the Feasibility of Remote Haemodynamic Monitoring in a Cohort of Multi-ethnic Chronic Stroke Patients Using a Novel User Interface and Artificial Intelligence Algorithms

Sponsor

University of Leicester

Enrollment

140 participants

Start Date

Mar 17, 2023

Study Type

OBSERVATIONAL

Conditions

Dementia Depression Cognitive Dysfunction Stroke Delirium

Summary

The goal of this observational study is to determine the feasibility of using integrated Transcranial Doppler Ultrasonography or Near Infrared Spectroscopy to detect changes in cerebral autoregulation and neurovascular coupling in healthy, stroke, dementia, depression and delirium populations. We also aim to: * Determine the optimal stimulus for neurovascular coupling * To derive sample size estimates for a future study * To develop a multilevel, multivariate model that can be applied to future datasets

Eligibility

Min Age: 65 Years

Inclusion Criteria5

Healthy adults aged over 65 years, free from medical comorbidities or medications that can adversely affect cognitive function or cerebral haemodynamics;
Stable, well controlled comorbidities (e.g. hypertension);
A diagnosis of dementia (major neurocognitive disorder), depression, or delirium, according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V) criteria;
Participants on or off anti-dementia drug therapy (acetylcholinesterase inhibitors, NMDA receptor antagonists), and antidepressants;
A diagnosis of ischaemic (IS) or haemorrhagic (ICH) stroke according to clinical and/or radiological findings, within 72 hours of symptom onset

Exclusion Criteria3

Poorly controlled medical comorbidities affecting cerebral haemodynamics or cognitive function (e.g., heart failure, hypertension, type two diabetes);
Clinically unstable or too unwell to cooperate with the study protocol;
Lacks capacity or personal consultee to consent to the study.