RecruitingNot ApplicableNCT05676476

The ACHIEVE Trial: Achieving Longer Gestation in Preeclampsia Via Antihypertensive Therapy.


Sponsor

University of Alabama at Birmingham

Enrollment

132 participants

Start Date

Feb 14, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The Achieve Trial is a randomized clinical trial to test whether lowering blood pressure to less than 140/90 mmHg in women with hypertensive disorders of pregnancy will prolong pregnancy.


Eligibility

Sex: FEMALEMin Age: 14 YearsMax Age: 49 Years

Plain Language Summary

Simplified for easier understanding

This study — called the ACHIEVE Trial — is testing whether giving blood pressure medication to pregnant women with mild high blood pressure or early preeclampsia can safely extend the pregnancy and delay the need for early delivery, potentially improving outcomes for both mother and baby. **You may be eligible if...** - You are pregnant between 23 and 35 weeks and 6 days - You have been diagnosed with gestational high blood pressure or preeclampsia without severe features - You are carrying a single baby or dichorionic twins - Your membranes are intact and your doctor plans to manage your pregnancy expectantly (not deliver immediately) **You may NOT be eligible if...** - Your preeclampsia has severe features (very high blood pressure, low platelets, liver or kidney problems, lung fluid, or neurological symptoms) - You have pre-existing kidney disease or stage 2 chronic high blood pressure - Your baby has growth restriction or low amniotic fluid - You cannot take the study medications (labetalol or nifedipine) - There is a known major fetal abnormality Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAntihypertensive treatment

Antihypertensive treatment to goal of less than 140/90 mmHg


Locations(2)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Oschner

New Orleans, Louisiana, United States

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NCT05676476


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