RecruitingNCT05679206

Antiphospholipid Syndrome and Postpartum Pulmonary Artery Pressure

Association Between Preeclampsia, Antiphospholipid Syndrome and Postpartum Pulmonary Artery Pressure, Systemic Arterial Pressure and Cardiovascular Function.


Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

900 participants

Start Date

Dec 20, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The primary goal of this observational study is to learn about postpartum pulmonary artery pressure in women who suffered from Preeclampsia and Antiphospholipid Syndrome. The main question it aims to answer is whether the conjunction of preeclampsia with obstetric antiphospholipid syndrome significantly foster the development of long-lasting pulmonary hypertension. Only participants who suffered from preeclampsia during pregnancy will be followed for a period up to 3 years postpartum. Researchers will compare women with or without obstetric antiphospholipid syndrome.


Eligibility

Sex: FEMALEMin Age: 16 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring blood pressure in the lungs (pulmonary artery pressure) after childbirth in women who experienced preeclampsia during pregnancy. Researchers also want to understand whether an antibody condition called antiphospholipid syndrome plays a role in complications affecting the heart and lungs after a preeclamptic pregnancy. **You may be eligible if...** - You are 16 or older - You were diagnosed with preeclampsia during your pregnancy (defined as new high blood pressure after 20 weeks along with protein in urine or other organ involvement) - You are receiving follow-up care at the relevant obstetric and cardiology clinic in Bern, Switzerland **You may NOT be eligible if...** - You are under 16 years old - Your medical records are incomplete or unclear enough to confirm diagnosis or analyze the main outcome Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTEchocardiography images

Transthoracic echocardiographic (Vivid E95) performed in all included patients between three months and three years after delivery. * Left ventricular ejection fraction, * Left ventricular mass index, * Septal and lateral mitral annular E-wave velocity assessed by tissue Doppler, * Tricuspid annular plane systolic excursion, * Left atrial volume index, * Right ventricle to right atrium (RV/RA) gradient

DIAGNOSTIC_TEST24-hour ambulatory blood pressure monitoring

Twenty-four-hour ABPM performed between three months and three years after delivery using validated recorders (Spacelabs model 90217, USA)


Locations(1)

Inselspital

Bern, Switzerland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05679206


Related Trials