Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE)

This study (CLODETTE) investigates the link between clonal hematopoiesis — a condition where a subset of blood stem cells carries mutations — and an increased risk of unusual or unexplained blood clots (venous thrombosis) in young people. Researchers suspect that certain genetic mutations in blood cells may predispose people to clotting events even in the absence of traditional risk factors. Blood samples from patients under 50 with unexplained clots will be analyzed to test this hypothesis. You may be eligible if: - You are under 50 years old - You have experienced an unexplained venous thrombosis, including: splanchnic or cerebral vein clot, upper limb deep vein thrombosis, an unprovoked pulmonary embolism, or a combination of DVT and arterial clot You may NOT be eligible if: - Your clot was triggered by a major or temporary risk factor (recent surgery, leg fracture, hormonal contraceptives, pregnancy, prolonged immobilization, or long travel) - You have an active cancer - You have a chronic inflammatory disease - You are currently on heparin therapy - You have a known thrombophilia (protein C or S deficiency, antithrombin deficiency, Factor II or V mutation, antiphospholipid syndrome, myeloproliferative neoplasm, or paroxysmal nocturnal hemoglobinuria) Talk to your doctor to see if this trial is right for you.