Pre-malignant States to Hematologic Malignancies in Firefighters
Wake Forest University Health Sciences
300 participants
Mar 1, 2026
OBSERVATIONAL
Conditions
Summary
The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.
Eligibility
Inclusion Criteria4
- Written informed consent and HIPAA authorization for release of personal health information.
- Age ≥ 40-49 years at the time of consent (self-reported)
- Ability of the participant to understand and comply with study procedures for the entire length of the study
- Currently employed by Charlotte Fire Department (CFD) with at least 5 years on-the -job experience (self-reported)
Exclusion Criteria1
- Anyone with a current diagnosis of a hematologic malignancy will be excluded.
Interventions
Whole blood will be collected at the Baseline visit to evaluate for monoclonal gammopathy through SPEP, immunofixation, and free light chains.
Whole blood will be collected at the Baseline visit for CBC with differential which may inform a diagnosis of a plasma cell disorder or other hematological disorder.
Whole blood will be collected at the Baseline visit to be evaluated using next generation sequencing (NGS) detection of CHIP. Deep NGS to identify mutations associated with myeloid neoplasms and CHIP will be performed using an error-correcting next generation sequencing multi-gene panel targeting genes most frequently mutated in CHIP.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06870760