RecruitingNCT05734378

Prognosis of Cerebral Small Vessel Disease

Prognosis of Cerebral Small Vessel Disease - a Prospective Cohort Study (PRO-SVD)

Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

900 participants

Start Date

Dec 1, 2020

Study Type

OBSERVATIONAL

Conditions

Cerebral Amyloid Angiopathy Cadasil Small Vessel Cerebrovascular Disease CAA - Cerebral Amyloid Angiopathy

Summary

Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.

Eligibility

Min Age: 16 Years

Inclusion Criteria3

Hypertensive deep perforator arteriolopathy (DPA), clinically symptomatic with either ICH, ischaemic stroke, cognitive impairment or severe radiological manifestation (Fazekas ≥II)
Cerebral amyloid angiopathy (CAA according to modified Boston or Edinburgh criteria), clinically symptomatic with either ICH (including cSAH), amyloid spells, cognitive impairment or severe radiological manifestation (CMB≥2)
Other SVD (i.e. CADASIL or other sporadic or genetic SVD)

Exclusion Criteria2

Life expectancy of \<6 months due to not-SVD related causes (i.e. cancer)
Patient is unlikely to attend follow-up visits

Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.

Locations(1)

Department of Neurology, Inselspital Bern University Hospital

Bern, Switzerland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05734378

Related Trials

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

NCT0639371257 locations

Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)

NCT067140971 location