Long-term Prospective Study of Korean CADASIL Patients
Long-term Prognosis of Korean Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy(CADASIL) Patients: A Multicenter Prospective Study
Jeju National University Hospital
500 participants
Jul 10, 2023
OBSERVATIONAL
Conditions
Summary
K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia. The investigators will track symptoms, brain scans, memory tests, and gene information to understand disease progression in Koreans and identify better treatments. Participants will visit clinics regularly for check-ups and blood tests. This study aims to help improve care for CADASIL patients and families worldwide.
Eligibility
Inclusion Criteria3
- Age ≥ 19 years
- CADASIL suspected or confirmed by genetic testing (NOTCH3 mutation)
- Able to provide written informed consent (participant or legally authorized representative)
Exclusion Criteria2
- Contraindication to MRI (claustrophobia, metal implants, pacemaker)
- Acute ischemic or hemorrhagic stroke within 180 days prior to enrollment
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07497867