RecruitingNot ApplicableNCT05752760

Pilot Study Lp299v Supplementation in Chronic Heart Failure

Impact of Lactobacillus Plantarum 299v Probiotic Supplementation on Vascular Function and Exercise Capacity in Chronic Heart Failure With Reduced and Preserved Ejection Fraction.

Sponsor

Medical College of Wisconsin

Enrollment

20 participants

Start Date

Feb 20, 2023

Study Type

INTERVENTIONAL

Conditions

Heart Failure Heart Failure With Reduced Ejection Fraction Heart Failure With Preserved Ejection Fraction Heart Failure, Diastolic Heart Failure, Systolic

Summary

The goal of this study is to determine the impact of 12 weeks of Lp299v supplementation (20 million cfu/day vs. placebo) on exercise capacity, circulating biomarkers of cardiac remodeling, quality of life, and vascular endothelial function in humans with heart failure and reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) who have evidence of residual inflammation based on an elevated C-reactive protein level. This will be done in the setting of a randomized, double-blind, placebo-controlled trial.

Eligibility

Min Age: 21 YearsMax Age: 89 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a probiotic supplement called Lactobacillus plantarum 299v (LP299V) can help people living with chronic heart failure feel better and improve their heart health. **You may be eligible if...** - You are between 21 and 89 years old - You have been diagnosed with congestive heart failure in the last 6 months - Your heart's pumping ability (ejection fraction) is 40% or lower, confirmed by an echocardiogram (heart ultrasound) **You may NOT be eligible if...** - You do not have documented systolic heart dysfunction - You have not had a recent echocardiogram confirming reduced heart function Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERLactobacillus Plantarum 299v Freeze Dried Capsule

The intervention is a probiotic lactobacillus that is contained in food products in the US

OTHERFreeze Dried Potato Starch Capsule

The intervention is potato starch that is freeze dried designed to mimic the lp299v capsule.

Locations(1)

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

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NCT05752760

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