RecruitingNot ApplicableNCT05783063

iTBS for Increased Appetite Induced by Antipsychotics

Effects of Intermittent Theta Burst Stimulation (iTBS) on Increased Appetite Induced by Antipsychotics in Patients With Schizophrenia

Sponsor

Central South University

Enrollment

60 participants

Start Date

Aug 1, 2023

Study Type

INTERVENTIONAL

Conditions

Schizophrenia

Summary

Antipsychotics are prone to cause metabolic side effects, including weight gain, hyperglycemia, insulin resistance, hyperlipidemia and so on, leading to a 2-3 times higher risk of death in patients with schizophrenia compared to healthy people. Conventional high-frequency rTMS have been used to treat people with obesity and showed certain effectiveness. However, studies involving schizophrenia patients and intermittent theta burst (iTBS) mode are rarely seen. The goal of this clinical trial is to evaluate the efficacy and safety of iTBS on ameliorating increased appetite induced by antipsychotics in people with schizophrenia.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) — a type of repetitive magnetic stimulation — can reduce weight gain caused by antipsychotic medications in people with schizophrenia. Antipsychotics often cause significant appetite increases and weight gain, and researchers are looking for ways to counteract this side effect. **You may be eligible if:** - You are between 18 and 40 years old - You have a diagnosis of schizophrenia (DSM-5 criteria) - You have gained more than 10% of your body weight after starting antipsychotics in the past year, or your BMI is 25 or above - You are currently on one or two antipsychotic medications (specific types listed in the criteria) - You have not received TMS (transcranial magnetic stimulation) treatment in the past month **You may NOT be eligible if:** - You are currently taking antidepressants, mood stabilizers, or other psychiatric medications beyond antipsychotics - You have a history of seizures or other contraindications to brain stimulation - You have received TMS in the past month Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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