RecruitingNCT05797649

Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)

Comparing N-terminal-proB-type Natriuretic Peptide with Other Diagnostic Criteria in Discriminating Heart Failure-associated from Non-heart Failure-associated Pleural Effusions

Sponsor

Chinese University of Hong Kong

Enrollment

120 participants

Start Date

Jul 1, 2023

Study Type

OBSERVATIONAL

Conditions

Heart Failure Malignant Neoplasm Cirrhosis Pleural Effusion Infections Renal Failure Fluid Overload Hypoalbuminemia

Summary

To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Patients hospitalized for heart failure and pleural effusion
Pleural tapping indicated for pleural fluid analysis.
Aged 18 years old or above

Exclusion Criteria4

History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.
History of surgical decortication or pleurodesis in the ipsilateral pleural space.
Ipsilateral thoracic or cardiac surgery in the past 3 months.
Failure to obtain informed consent due to the patient's refusal or cognitive impairment.