Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

This study is testing whether rosuvastatin (a common cholesterol-lowering medication) can slow liver disease progression in people with cirrhosis (advanced liver scarring) caused by fatty liver disease, alcohol-related liver disease, or treated hepatitis B or C. The goal is to see if this affordable medication can reduce liver stiffness and prevent serious complications. **You may be eligible if...** - You are between 18 and 75 years old - You have liver cirrhosis confirmed by biopsy or imaging/lab tests - Your cirrhosis is "compensated" — meaning you have not recently had fluid buildup, confusion (from liver failure), or bleeding from enlarged veins - Your liver stiffness on a special scan (elastography) is 15 kPa or higher **You may NOT be eligible if...** - You have had recent complications such as fluid buildup in the abdomen, episodes of confusion, or bleeding from your esophagus - You are on diuretics (water pills) for liver-related fluid retention - You have decompensated liver disease (liver is failing) Talk to your doctor to see if this trial is right for you.