Microbiome in Head and Neck Squamous Cell Carcinoma

This study is investigating the relationship between the bacteria and microorganisms living in and around oral squamous cell carcinoma (OSCC) — a type of mouth cancer — and the patient's immune response. Researchers want to understand whether specific microbiome patterns are associated with cancer development, which could help identify new prevention or treatment targets. **You may be eligible if...** - You are 18 or older - You are being seen at the University of Colorado otolaryngology (ear, nose, and throat) clinic - You have been diagnosed with oral squamous cell carcinoma (mouth cancer), OR - You are visiting the same clinic for unrelated reasons and match the age range of a cancer patient (to serve as a comparison) **You may NOT be eligible if...** - You are under 18 or over 100 years old - You are unwilling to participate Talk to your doctor to see if this trial is right for you.