Microbiome in Head and Neck Squamous Cell Carcinoma
Role of Human Microbiome in Head and Neck Cancer
University of Colorado, Denver
60 participants
May 23, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to determine whether dysbiosis actively contributes to HNSCC and if so, the underlying molecular mechanisms.
Eligibility
Inclusion Criteria5
- Subjects equal to or above the age of 18.
- Patients who are seen and evaluated by a provider within the adult Otolaryngology clinic at the University of Colorado Health.
- Patients that present with a diagnosis of OSCC.
- An equal number of age-matched patients who are visiting the clinic for reasons other than OSCC diagnoses, as the control group.
- Ability to understand and willingness to sign a written informed consent document
Exclusion Criteria2
- Subjects under the age of 18 or over the age of 100
- Subjects unwilling to particiapte
Interventions
Shotgun metagenomic sequencing will characterize cancer-associated changes in microbial functional capacity and species/strain-level taxonomic profiles. Metagenomics will provide data on microbial functional capacity along with broader taxonomic classifications.
Metabolic analysis will be conducted using LC/MS-based metabolic analysis. A targeted approach will quantify a panel of 30 compounds including Trp pathway products while a non-targeted approach, when applied to both lipid and aqueous phase compounds, will profile relative changes in compounds that may influence host
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05837221