Personalized Tumor Vaccines and Pabolizumab in Patients With Advanced Pancreatic Cancer

This study is testing a personalized cancer vaccine — made from your tumor's specific mutations — combined with the immunotherapy drug pembrolizumab (Keytruda) in people with advanced solid tumors including pancreatic cancer. **You may be eligible if...** - You are 18 or older - You have a locally advanced, recurrent, or metastatic solid tumor confirmed by biopsy - Your cancer has not responded to standard treatments - You have good performance status and adequate organ function - You are willing to provide tumor tissue samples for vaccine creation **You may NOT be eligible if...** - You have active brain metastases (unless stable) - You have active autoimmune disease requiring medication - You are pregnant or breastfeeding - You have had severe prior reactions to immunotherapy Talk to your doctor to see if this trial is right for you.