FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort
HÉRITABILITÉ FAMILIALE, INTERACTIONS GÈNE-GÈNE ET GÈNE-ENVIRONNEMENT DANS LE DOMAINE DES MALADIES CARDIOVASCULAIRES ET RENALES. Cinquième Visite de la Cohorte STANISLAS
Central Hospital, Nancy, France
3,000 participants
Jul 13, 2023
INTERVENTIONAL
Conditions
Summary
The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.
Eligibility
Inclusion Criteria4
- aged over 18
- Person who participated in the Stanislas Cohort
- Person affiliated to a social security scheme or beneficiary of such a scheme
- Person having received complete information on the organization of the research and having signed an informed consent
Exclusion Criteria5
- Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric treatment under Articles L. 3212-1 and L. 3213-1
- Person referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code:
- Pregnant woman, parturient or nursing mother
- Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
- Person of full age unable to express consent
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Interventions
Blood and urine samples
Blood samples
Echocardiography, Lung ultrasound, pulse wave velocity, carotid stiffness and thickness, Central and peripheral blood pressure, carotid pulse pressure, abdominal aorta ultrasound, jugular vein ultrasound, liver elastography (Optional).
Food frequency questionnaires, ''Dutch eating behaviour questionnaire'' and dietary supplement questionnaire
Measurement of height, weight, abdominal circumference, hip circumference, arm circumference
Systolic pressure index measurement
Heart rate measurements, blood pressure measurements, orthostatic BP measurements
Blood pressure measurements by "unattended BP" monitor over 5 min
Electrocardiogram
EVALOBS scale and compliance questionnaire
For the first 100 patients willing to participate
For the first 100 patients willing to participate. For biobank constitution and measurement of microalbuminuria, creatininuria, osmolarity, natriuresis, kaliuresis, urea, proteinuria and urine dipstick
Collection of socio-demographic data such as age, level of education, profession, household income, smoking status, physical activity, perception of health, prematurity, height and weight at birth, family and personal history especially cardiovascular (history of stroke, myocardial infarction, heart failure, current pathologies, drugs, tobacco...)
Women specific questionnaire
Women specific questionnaire
Determination of NYHA class.
Assessment of anxiety
sleep quality assessment
Patient's evaluation of cardiovascular risk factors by the health system
Assessment of eating behaviors
Assessement of eating habit to create a consumer profile
Evaluation od food supplements intake
SARS-CoV-2 Infection Questionnaire
Carbon monoxyde analysis in expired air
Capillary sampling for pollutant analysis (Optional)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05916287