RecruitingNot ApplicableNCT05943626

Circadian Intervention to Improve Cardiometabolic Health

Timing of Circadian Synchronizers: the TOCS Study

Sponsor

University of Utah

Enrollment

20 participants

Start Date

Jun 13, 2023

Study Type

INTERVENTIONAL

Conditions

Cardiometabolic Syndrome Sleep Type 2 Diabetes Overweight and Obesity Time Restricted Feeding Lifestyle Factors Insulin Sensitivity Eating Habit Sleep Hygiene

Summary

The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD). Participants will undergo a randomized controlled trial, with circadian intervention and control (healthy lifestyle) groups. The circadian intervention is designed to reduce nighttime light exposure and after-dinner snack food intake. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria3

Age: 18-45 years old; equal numbers of men and women
Body mass index (BMI): 25.0-34.9 kg/m2,
Sleep Habits: habitual self-reported average total sleep time (TST) \<6.5 hours per night for prior 6 months

Exclusion Criteria10

Clinically diagnosed sleep disorder or major psychiatric illness
Evidence of significant organ dysfunction or disease (e.g., diagnosed diabetes, cardiovascular disease, or kidney disease)
Use of prescription drugs or substances known to influence sleep or glucose metabolism
Shift-work: current or history of within last year
Weight change: \>10% of body weight over prior six months
Experiencing menopause or post-menopausal
Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program
Currently pregnant or planning to become pregnant, or currently lactating.
Currently smoking
Alcohol intake \>3 drinks per day or \>14 drinks per week

Interventions

BEHAVIORALCircadian Intervention

The circadian intervention group will receive counseling and instruction to reduce evening and nighttime light exposure, increase morning room light and sunlight exposure, and to finish all food consumption at least 4 hours before bedtime.